Which statement about mastitis in postpartum women is least accurate?

The statement that mastitis may occur as early as the first postpartum day is the least accurate because mastitis typically develops later in the postpartum period, often around two to three weeks after birth. This timing is associated with the onset of breastfeeding, as factors such as milk stasis and blocked ducts become more prevalent during this period, contributing to the risk of infection.

In contrast, the other statements about mastitis are more accurate. The condition indeed involves the interlobular connective tissue, which comprises the structural framework of the breast. Mastitis is also more common to affect only one breast rather than both, making localized signs and symptoms a key feature of this infection. Therefore, the timing of mastitis development makes the statement about its occurrence as early as the first postpartum day the least accurate.